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Review
. 2013 Jan;27(1):31-9.
doi: 10.1016/j.blre.2012.12.002. Epub 2012 Dec 20.

Extracellular vesicles in physiological and pathological conditions

Yuana Yuana  1 , Auguste Sturk, Rienk Nieuwland
Affiliations
Free article
Review

Extracellular vesicles in physiological and pathological conditions

Yuana Yuana et al. Blood Rev. 2013 Jan.
Free article

Abstract

Body fluids contain surprising numbers of cell-derived vesicles which are now thought to contribute to both physiology and pathology. Tools to improve the detection of vesicles are being developed and clinical applications using vesicles for diagnosis, prognosis, and therapy are under investigation. The increased understanding why cells release vesicles, how vesicles play a role in intercellular communication, and how vesicles may concurrently contribute to cellular homeostasis and host defense, reveals a very complex and sophisticated contribution of vesicles to health and disease.

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