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Review
. 2013 Apr;161(4):313-20.
doi: 10.1016/j.trsl.2012.11.004. Epub 2012 Dec 20.

Gene transfer for congestive heart failure: update 2013

Tong Tang  1 , H Kirk Hammond
Affiliations
Review

Gene transfer for congestive heart failure: update 2013

Tong Tang et al. Transl Res. 2013 Apr.

Abstract

Congestive heart failure is a major cause of morbidity and mortality with increasing social and economic costs. There have been no new high impact therapeutic agents for this devastating disease for more than a decade. However, many pivotal regulators of cardiac function have been identified using cardiac-directed transgene expression and gene deletion in preclinical studies. Some of these increase function of the failing heart. Altering the expression of these pivotal regulators using gene transfer is now either being tested in clinical gene transfer trials, or soon will be. In this review, we summarize recent progress in cardiac gene transfer for clinical congestive heart failure.

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Conflict of interest statement

Dr. Hammond is founder, consultant, and equity holder in Renova Therapeutics, which was not involved in any manner with the studies reviewed. Dr. Tang has no conflict of interest.

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