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. 2013 Jan-Feb;7(1):44-7.
doi: 10.4161/cam.23276. Epub 2012 Dec 21.

The laminin family: founding members of the basement membrane

Patricia Simon-Assmann

The laminin family: founding members of the basement membrane

Patricia Simon-Assmann. Cell Adh Migr. 2013 Jan-Feb.
No abstract available

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About Dr Patricia Simon-Assmann 
Dr Patricia Simon-Assmann received her PhD in Biochemistry from the Université Louis Pasteur (Strasbourg, France) in 1979. Under the supervision of Dr Katy Haffen (a disciple of the famous embryologist E. Wolff) she studied the control of maturation of digestive enzymes by in vitro organ cultures and in vivo. After that, she joined James C. Thompson, professor and chairman of the Department of Surgery, University of Texas Medical Branch (Galveston, TX) as a postdoctoral fellow and elucidated the physiological and pathological roles of gastrin and other gut peptides. Upon her return to France she obtained a permanent position at CNRS in 1982 and has worked since then in an INSERM laboratory in Strasbourg dedicated to development and cancer research. Together with M. Kedinger she has contributed to the important discovery that epithelial-mesenchymal cell interactions are required for cell differentiation and intestinal morphogenesis. She is known for her work in the field of extracellular matrix, having discovered the importance of fibroblasts in the deposition and assembly of basement membrane components by creating chimeric intestines, a strategy developed by her. A major focus of her work are laminins. She demonstrated that these secreted molecules play an essential role in tissue architecture, epithelial cell differentiation, signaling and transcription factor activity. Her results are highly relevant for intestinal pathologies such as inflammatory bowel diseases and colon cancer where laminin expression is deregulated.
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References

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