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. 2012;9(1):e41-e49.
doi: 10.1016/j.ddstr.2012.06.001.

Treatment for Uterine Fibroids: Searching for Effective Drug Therapies

Darlene K Taylor  1 , Phyllis C Leppert
Affiliations

Treatment for Uterine Fibroids: Searching for Effective Drug Therapies

Darlene K Taylor et al. Drug Discov Today Ther Strateg. 2012.

Abstract

Uterine fibroids are common reproductive-age benign tumors that contribute to severe morbidity and infertility. Cumulative incidence is 4 times higher in Africian-Americans compared to Caucasians and constitutes a major health disparity challenge. Fibroids are the leading indication for hysterectomy and their management averages $21 billion annually in the US. No long term minimally invasive therapies exist. Thus, promising drug therapies, their chemistry, pharmacology, and clinical efficacy, focusing first on innovative drug delivery approaches, are reviewed.

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Conflict of interest statement

Conflict of interest

The authors have no conflict of interest to declare.

Figures

Figure 1
Figure 1
GnRH Agonist Structures. Modifications at positions 6 and 10 are the basis for development of variety of GnRHa.
Figure 2
Figure 2
Structures of Progestins and SPRMs. Comparison of the chemical structures of progesterone and Progesterone receptor (PR) agonists (progestins) and selective PR modulators (SPRMs;PR anatagonists with PR agonisitic properties). Small structural changes account for important differences in the effects of compounds on PR. As a point of reference, the steroid skeleton is also shown with the rings named and the positions numbered according to commonly used nomenclature.
See this image and copyright information in PMC

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