Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec 18:2:183.
doi: 10.3389/fonc.2012.00183. eCollection 2012.

SULT1A1 genetic polymorphisms and the association between smoking and oral cancer in a case-control study in Brazil

Sabrina S Santos  1 , Rosalina J Koifman, Rafaela M Ferreira, Lilian F Diniz, Paul Brennan, Paolo Boffetta, Sergio Koifman
Affiliations

SULT1A1 genetic polymorphisms and the association between smoking and oral cancer in a case-control study in Brazil

Sabrina S Santos et al. Front Oncol. .

Abstract

Introduction: Oral cancer is a public health problem worldwide, being tobacco and alcohol consumption their main risk factors. Sulfotransferase (SULT) 1A1 (encoded by SULT1A1) is involved in procarcinogens metabolism, such as polycyclic aromatic hydrocarbons (PAHs) present in tobacco smoke.

Objective: The aim of this study was to explore the magnitude of association between SULT1A1 gene Arg(213)His polymorphism and oral cancer, and to explore the interaction between such polymorphism and smoking.

Methods: A hospital-based case-control study was carried out in Rio de Janeiro, Brazil, during 1999-2002. Epidemiological data and biological samples were obtained from 202 oral cancer patients and 196 sex and age-frequency matched controls without cancer antecedents.

Results: No association was observed between Arg(213)His SULT1A1 polymorphism and oral cancer risk in overall analysis (OR = 1.06, 95% CI = 0.71-1.57). The magnitude of association between cigarette smoking and oral cancer was higher in individuals with a SULT1A1(*)1 isoform (wild type, genotype Arg/Arg) (OR = 10.19, 95% CI = 3.90-26.61) than in those with at least one SULT1A1(*)2 allele (genotypes Arg/His + His/His) (OR = 4.50, 95% CI =2.09-9.69).

Conclusion: Our results suggest that Arg(213)His SULT1A1 polymorphism may modulate the association between smoking and oral cancer. However, this association needs to be replicated in other studies: due to modest number of cases and controls, the role of chance in the observed association cannot be ruled out.

Keywords: SULT 1A1 gene; alcohol; oral cancer; polymorphisms; smoking.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Anantharaman D., Marron M., Lagiou P., Samoli E., Ahrens W., Pohlabeln H., et al. (2011). Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncol. 47, 725–731 10.1016/j.oraloncology.2011.05.004 - DOI - PubMed
    1. Bardakci F., Arslan S., Bardakci S., Binatli A. O., Budak M. (2008). Sulfotransferase 1A1 (SULT1A1) polymorphism and susceptibility to primary brain tumors. J. Cancer Res. Clin. Oncol. 134, 109–114 10.1007/s00432-007-0256-3 - DOI - PubMed
    1. Boccia S., Persiani R., La Torre G., Rausei S., Arzani D., Gianfagna F., et al. (2005). Sulfotransferase 1A1 polymorphism and gastric cancer risk: a pilot case-control study. Cancer Lett. 229, 235–243 10.1016/j.canlet.2005.06.035 - DOI - PubMed
    1. Castellsagué X., Quintana M. J., Martínez M. C., Nieto A., Sánchez M. J., Juan A., et al. (2004). The role of type of tobacco and type of alcoholic beverage in oral carcinogenesis. Int. J. Cancer 108, 741–749 10.1002/ijc.11627 - DOI - PubMed
    1. Chung Y. T., Hsieh L. L., Chen I. H., Liao C. T., Liou S. H., Chi C. W., et al. (2009). Sulfotransferase 1A1 haplotypes associated with oral squamous cell carcinoma susceptibility in male Taiwanese. Carcinogenesis 30, 286–294 10.1093/carcin/bgn283 - DOI - PubMed

LinkOut - more resources