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. 2013 Apr;28(2):126-32.
doi: 10.1016/j.jcrc.2012.10.013. Epub 2012 Dec 21.

Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit

Gijs Fortrie  1 , Susanne Stads, Hilde R H de Geus, A B Johan Groeneveld, Robert Zietse, Michiel G H Betjes
Affiliations

Determinants of renal function at hospital discharge of patients treated with renal replacement therapy in the intensive care unit

Gijs Fortrie et al. J Crit Care. 2013 Apr.

Abstract

Purpose: Identification of risk factors for impaired renal function at hospital discharge in critically ill patients with acute kidney injury (AKI) requiring renal replacement therapy (RRT).

Methods: A single-center retrospective cohort study was performed evaluating demographic and clinical parameters as potential risk factors for a modest to severely impaired renal function at hospital discharge in patients with AKI requiring RRT in the intensive care unit.

Results: Of the 353 patients in our cohort, 90 (25.5%) patients had pre-existing chronic kidney disease (CKD). An estimated glomerular filtration rate (eGFR) ≤60 mL min(-1) 1.73 m(-2) at hospital discharge occurred in 64.0% of which 63.7% without known renal impairment before hospital admission and 8.2% of all cases left the hospital dialysis-dependent. Multivariable logistic regression showed that age (OR = 1.051, P < .001), serum creatinine concentration at start of RRT (OR = 1.004, P < .001) and administration of iodine-containing contrast fluid (OR = 0.830, P = .045) were associated with an eGFR ≤60 mL min(-1) 1.73 m(-2). Furthermore, a medical history of CKD (OR = 5.865, P < .001) was associated with dialysis dependence.

Conclusions: Elderly and patients with pre-existing CKD are at a high risk for modest to severely impaired renal function at hospital discharge after AKI requiring RRT.

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