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Clinical Trial
. 2013 Jan;14(1):87-9.
doi: 10.1016/j.eatbeh.2012.11.001. Epub 2012 Nov 19.

N-acetylcysteine in bulimia nervosa--open-label trial

Anna I Guerdjikova  1 , Thomas J Blom, Nicole Mori, Susan L McElroy
Affiliations
Clinical Trial

N-acetylcysteine in bulimia nervosa--open-label trial

Anna I Guerdjikova et al. Eat Behav. 2013 Jan.

Abstract

The objective of this 12-week open-label flexible-dose study was to preliminarily assess the effectiveness of N-acetylcysteine (NAC) in bulimia nervosa (BN). The primary outcome was binge-purge episode frequency. Eight individuals with BN by DSM-IV criteria received NAC, but only two completed the study. NAC was not associated with significant reductions in frequency of binge-purge episodes or measures of clinical severity, eating, or mood pathology. In this trial, NAC was ineffective in BN and was associated with a high discontinuation rate.

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