Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Sep;106(5):275-9.
doi: 10.1179/2047773212Y.0000000026.

Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment

Affiliations
Review

Edema surrounding calcified intracranial cysticerci: clinical manifestations, natural history, and treatment

Theodore Nash. Pathog Glob Health. 2012 Sep.

Abstract

Calcified granulomas are the most common radiological finding in neurocysticercosis (10-20% of endemic populations). A small proportion serves as foci of seizure activity, which results in large numbers of persons with epilepsy. Calcified granulomas are not all the same. Some demonstrate blood-brain barrier dysfunction (magnetic resonance imaging enhancement) most likely due to the presence of inflammation, visualizable scolices, and/or gliosis. About half the patients with a recent history of seizures, positive serology, and only calcified lesions develop perilesional edema at the time of a seizure recurrence. The natural history, treatment, and pathophysiology of this phenomenon are not well studied. Episodes are usually associated with seizures or other neurological manifestations, resolve by 4-6 weeks, sometimes occur repeatedly, and usually involve a subset of the same calcifications. Treatment is supportive. Histopathological examination of one calcification associated with multiple perilesional edema episodes revealed significant inflammation and supports the concept that perilesional edema is inflammatory in nature. This most likely is due to host responses to released or newly recognized parasite antigen and/or upregulation of the host immune response. Immunosuppressive and anti-inflammatory agents may be useful in prevention and/or treatment of this phenomenon.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A joining fast attenuated fluid inversion post-gadolinium injection images of a patient who presented with seizures associated with perilesional edema around a calcification in the left frontal lobe. Repeated episodes involving the same and other calcifications have been documented. The right image demonstrates an enhancing calcification with some edema, which is better visualized in the left image.

Similar articles

Cited by

References

    1. Hennenberg R.Die tierischen Parasiten des Zentralnervensystems Lewandowsky M, ed, editor. Handbuch der neurologie Berlin: Springer; 1912Vol. 3, pp. 642–83.
    1. Escobar A.Pathology of the nervous system Palacios E, Rodriguez-Carbajal J, Taveras J M, editors. Cysticercosis of the central nervous system Springfield, IL: Charles Thomas; 1983. pp. 27–54.
    1. Nash TE, Garcia HH. Diagnosis and treatment of neurocysticercosis. Nat Rev Neurol. 2011;7:584–94. - PMC - PubMed
    1. Nash TE, Del Brutto OH, Butman JA, Corona T, Delgado-Escueta A, Duron RM, et al. Calcific neurocysticercosis and epileptogenesis. Neurology. 2004;62:1934–8. - PMC - PubMed
    1. Fleury A, Gomez T, Alvarez I, Meza D, Huerta M, Chavarria A, et al. High prevalence of calcified silent neurocysticercosis in a rural village of Mexico. Neuroepidemiology. 2003;22:139–45. - PubMed

Publication types

Substances

LinkOut - more resources