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. 2013 Feb 1;23(3):715-9.
doi: 10.1016/j.bmcl.2012.11.102. Epub 2012 Dec 2.

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

Murat Bozdag  1 , Tobias Dreker, Christophe Henry, Paolo Tosco, Maura Vallaro, Roberta Fruttero, Andrea Scozzafava, Fabrizio Carta, Claudiu T Supuran
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Free article

Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors

Murat Bozdag et al. Bioorg Med Chem Lett. .
Free article

Abstract

Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.

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