Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Apr 30;331(1):18-23.
doi: 10.1016/j.canlet.2012.12.013. Epub 2012 Dec 23.

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

Anders Christiansen  1 , Lars Dyrskjøt
Affiliations
Review

The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer

Anders Christiansen et al. Cancer Lett. .

Abstract

In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the translocation of several cancer-associated proteins. We provide an overview of the clinical studies that have established the biomarker potential of KPNA2 and describe its functional role with an emphasis on established associations with cancer.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Cellular processes and interaction partners associated with KPNA2. Details concerning the listed interaction partners can be found in the text. Note that, albeit interaction with KPNA2 has been demonstrated, alternate karyopherins may also partake in the translocation of the listed proteins.
See this image and copyright information in PMC

References

    1. Kau T.R., Way J.C., Silver P.A. Nuclear transport and cancer: from mechanism to intervention. Nat. Rev. Cancer. 2004;4:106–117. - PubMed
    1. Stewart M. Molecular mechanism of the nuclear protein import cycle. Nat. Rev. Mol. Cell Biol. 2007;8:195–208. - PubMed
    1. Goldfarb D.S., Corbett A.H., Mason D.A., Harreman M.T., Adam S.A. Importin alpha: a multipurpose nuclear-transport receptor. Trends Cell Biol. 2004;14:505–514. - PubMed
    1. Kelley J.B., Talley A.M., Spencer A., Gioeli D., Paschal B.M. Karyopherin alpha7 (KPNA7), a divergent member of the importin alpha family of nuclear import receptors. BMC Cell Biol. 2010;11:63. - PMC - PubMed
    1. Radu A., Blobel G., Moore M.S. Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. Proc. Natl. Acad. Sci. USA. 1995;92:1769–1773. - PMC - PubMed