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Comment
. 2012 Dec 26;13(12):182.
doi: 10.1186/gb-2012-13-12-182.

A new era of human population genetics

Comment

A new era of human population genetics

Alexander Platt et al. Genome Biol. .

Abstract

The 1000 Genomes Project Consortium has recently published an important early contribution to a new generation of systematic surveys of rare human genetic variation.

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Comment on

  • An integrated map of genetic variation from 1,092 human genomes.
    1000 Genomes Project Consortium; Abecasis GR, Auton A, Brooks LD, DePristo MA, Durbin RM, Handsaker RE, Kang HM, Marth GT, McVean GA. 1000 Genomes Project Consortium, et al. Nature. 2012 Nov 1;491(7422):56-65. doi: 10.1038/nature11632. Nature. 2012. PMID: 23128226 Free PMC article.

References

    1. The 1000 Genomes Project Consortium. An integrated map of genetic variation from 1,092 human genomes. Nature. 2012;491:56–65. doi: 10.1038/nature11632. - DOI - PMC - PubMed
    1. Ohta T, Gillespie JH. Development of neutral and nearly neutral theories. Theor Popul Biol. 1996;49:128–142. doi: 10.1006/tpbi.1996.0007. - DOI - PubMed
    1. Crow JF. Population genetics history: a personal view. Annu Rev Genet. 1987;21:1–22. doi: 10.1146/annurev.ge.21.120187.000245. - DOI - PubMed
    1. Coventry A, Bull-Otterson LM, Liu X, Clark AG, Maxwell TJ, Crosby J, Hixson JE, Rea TJ, Muzny DM, Lewis LR, Wheeler DA, Sabo A, Lusk C, Weiss KG, Akbar H, Cree A, Hawes AC, Newsham I, Varghese RT, Villasana D, Gross S, Joshi V, Santibanez J, Morgan M, Chang K, Iv WH, Templeton AR, Boerwinkle E, Gibbs R, Sing CF. Deep resequencing reveals excess rare recent variants consistent with explosive population growth. Nat Commun. 2010;1:131. doi: 10.1038/ncomms1130. - DOI - PMC - PubMed
    1. Nelson MR, Wegmann D, Ehm MG, Kessner D, St Jean P, Verzilli C, Shen J, Tang Z, Bacanu SA, Fraser D, Warren L, Aponte J, Zawistowski M, Liu X, Zhang H, Zhang Y, Li J, Li Y, Li L, Woollard P, Topp S, Hall MD, Nangle K, Wang J, Abecasis G, Cardon LR, Zöllner S, Whittaker JC, Chissoe SL, Novembre J. et al.An abundance of rare functional variants in 202 drug target genes sequenced in 14,002 people. Science. 2012;337:100–104. doi: 10.1126/science.1217876. - DOI - PMC - PubMed

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