doi: 10.1021/ja312150d.
Epub 2012 Dec 31.
Enantioselective total synthesis of hyperforin
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- PMID: 23270309
- DOI: 10.1021/ja312150d
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Enantioselective total synthesis of hyperforin
J Am Chem Soc.
.
Abstract
A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.
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