Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2011 Jul;20(2):131-3.
doi: 10.4103/0972-6748.102517.

Stevens-Johnson syndrome progressing to toxic epidermal necrolysis with haloperidol and carbamazepine combination

Ajay Kumar  1 , Sukanto Sarkar, Samir Kumar Praharaj, Sayeed Akhtar, M Diwakar
Affiliations
Case Reports

Stevens-Johnson syndrome progressing to toxic epidermal necrolysis with haloperidol and carbamazepine combination

Ajay Kumar et al. Ind Psychiatry J. 2011 Jul.

Abstract

Carbamazepine and other anticonvulsants are commoner cause of severe adverse cutaneous drug reactions such as erythema multiforme, toxic epidermal necrolysis (TEN), and Stevens-Johnson syndrome (SJS). We report a case of SJS rapidly progressing to TEN with a combination of haloperidol and carbamazepine in a patient with bipolar affective disorder. The pathophysiological mechanism underlying this reaction is discussed.

Keywords: Carbamazepine; Stevens–Johnson syndrome; haloperidol; toxic epidermal necrolysis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared

Figures

Figure 1
Figure 1
Vesico-bullous lesions over face and neck with swelling of eyelids and ulceration over lips
See this image and copyright information in PMC

References

    1. Bastuji-Garin S, Rzany B, Stern RS, Shear NH, Naldi L, Roujeau JC. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993;129:92–6. - PubMed
    1. Devi K, George S, Criton S, Suja V, Sridevi PK. Carbamazepine-the commonest cause of toxic epidermal necrolysis and Stevens-Johnson syndrome: A study of 7 years. Indian J Dermatol Venereol Leprol. 2005;71:325–8. - PubMed
    1. Roujeau JC, Stern RS. Severe Adverse Cutaneous Reactions to drugs. N Engl J Med. 1994;331:1272–85. - PubMed
    1. Summary of product characteristics. Haloperidol. [Last accessed on 2010 Mar 20]. Available from: http://emc.medicines.org.uk/medicine/17426/SPC/Haldol 10mg Tablets/
    1. Wong KE. Stevens-Johnson syndrome in neuroleptic-carbamazepine combination. Singapore Med J. 1990;31:432–3. - PubMed

Publication types