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. 2013 Feb 1;78(3):1242-8.
doi: 10.1021/jo302471z. Epub 2013 Jan 7.

Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines

Jinsong Peng  1 , Guoning Shang, Chunxia Chen, Zhongshuo Miao, Bin Li
Affiliations

Nucleophilic addition of benzimidazoles to alkynyl bromides/palladium-catalyzed intramolecular C-H vinylation: synthesis of benzo[4,5]imidazo[2,1-a]isoquinolines

Jinsong Peng et al. J Org Chem. .

Abstract

An efficient "one-pot" route for the synthesis of benzo[4,5]imidazo[2,1-a] isoquinolines has been developed via nucleophilic addition of 2-aryl benzimidazoles to alkynyl bromides and subsequent palladium-catalyzed intramolecular C-H vinylation.

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