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. 2013 Mar 15:448:48-55.
doi: 10.1016/j.scitotenv.2012.11.070. Epub 2012 Dec 27.

Air pollution and respiratory symptoms among children with asthma: vulnerability by corticosteroid use and residence area

Toby C Lewis  1 , Thomas G Robins, Graciela B Mentz, Xiaohui Zhang, Bhramar Mukherjee, Xihong Lin, Gerald J Keeler, J Timothy Dvonch, Fuyuen Y Yip, Marie S O'Neill, Edith A Parker, Barbara A Israel, Paul T Max, Angela Reyes; Community Action Against Asthma (CAAA) Steering Committee
Affiliations

Air pollution and respiratory symptoms among children with asthma: vulnerability by corticosteroid use and residence area

Toby C Lewis et al. Sci Total Environ. .

Abstract

Rationale: Information on how ambient air pollution affects susceptible populations is needed to ensure protective air quality standards.

Objectives: To estimate the effect of community-level ambient particulate matter (PM) and ozone (O) on respiratory symptoms among primarily African-American and Latino, lower-income asthmatic children living in Detroit, Michigan and to evaluate factors associated with heterogeneity in observed health effects.

Methods: A cohort of 298 children with asthma was studied prospectively from 1999 to 2002. For 14days each season over 11 seasons, children completed a respiratory symptom diary. Simultaneously, ambient pollutant concentrations were measured at two community-level monitoring sites. Logistic regression models using generalized estimating equations were fit for each respiratory symptom in single pollutant models, looking for interactions by area or by corticosteroid use, a marker of more severe asthma. Exposures of interest were: daily concentrations of PM<10μm, <2.5μm, and between 10 and 2.5μm in aerodynamic diameter (PM, PM, and PM respectively), the daily 8-hour maximum concentration of O (8HrPeak), and the daily 1-hour maximum concentration of O (1HrPeak).

Results: Outdoor PM, PM, 8HrPeak, and 1HrPeak O concentrations were associated with increased odds of respiratory symptoms, particularly among children using corticosteroid medication and among children living in the southwest community of Detroit. Similar patterns of associations were not seen with PM.

Conclusions: PM and O at levels near or below annual standard levels are associated with negative health impact in this population of asthmatic children. Variation in effects within the city of Detroit and among the subgroup using steroids emphasizes the importance of spatially refined exposure assessment and the need for further studies to elucidate mechanisms and effective risk reduction interventions.

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Figures

Fig. 1
Fig. 1
OR point estimates and 95% confidence intervals of associations of ambient PM2.5, PM10–2.5, PM10, O3-8HrPeak and O3-1HrPeak concentrations with symptoms among children with asthma. 1A. PM2.5 general model. 1B. PM10–2.5 general model. 1C. O3-8HrPeak general model. 1D. O3-1Hr peak general model.
Fig. 2
Fig. 2
OR estimates and 95% confidence intervals of associations of ambient PM2.5, PM10–2.5, O3-8HrPeak and O3-1HrPeak concentrations with symptoms among children with asthma by corticosteroid use. 2A. PM2.5 by steroid use. 2B. PM10–2.5 by steroid use. 2C. O3-8Hr by steroid use. 2D. O3-1Hr by steroid use.
Fig. 3
Fig. 3
OR point estimates and 95% confidence intervals of associations of ambient PM2.5, PM10–2.5, O3-8HrPeak and O3-1HrPeak concentrations with symptoms among children with asthma by location. 3A. PM2.5 by location. 3B. PM10–2.5 by location. 3C. O3-8Hr by location. 3D. O3-1Hr by location.
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References

    1. Brook RD, Rajagopalan S, Pope CA, III, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation. 2010;121(21):2331–78. - PubMed
    1. Dales R, Chen L, Frescura AM, Liu L, Villeneuve PJ. Acute effects of outdoor air pollution on forced expiratory volume in 1 s: a panel study of schoolchildren with asthma. Eur Respir J. 2009;34(2):316–23. - PubMed
    1. Delfino RJ, Zeiger RS, Seltzer JM, Street DH, McLaren CE. Association of asthma symptoms with peak particulate air pollution and effect modification by anti-inflammatory medication use. Environ Health Perspect. 2002;110(10):607–17. - PMC - PubMed
    1. Dennekamp M, Akram M, Abramson MJ, Tonkin A, Sim MR, Fridman M, et al. Outdoor air pollution as a trigger for out-of-hospital cardiac arrests. Epidemiology. 2010;21(4):494–500. - PubMed
    1. Dominici F, McDermott A, Daniels M, Zeger SL, Samet JM. Revised analyses of the National Morbidity, Mortality, and Air Pollution Study: mortality among residents of 90 cities. J Toxicol Environ Health A. 2005;68(13–14):1071–92. - PubMed

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