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Comment
. 2012 Dec 27;2(6):1473-4.
doi: 10.1016/j.celrep.2012.12.004.

The longevity of sirtuins

David Sinclair  1 , Eric Verdin
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The longevity of sirtuins

David Sinclair et al. Cell Rep. .
Free article

Abstract

Controversy has recently arisen over the role of sirtuins in metazoan aging. In this issue of Cell Reports, Banerjee et al. demonstrate that Drosophila Sir2 is necessary for life span extension in response to dietary restriction and that its overexpression in the fat body increases the life span.

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