Dysembryoplastic neuroepithelial tumors: epileptogenicity related to histologic subtypes

Abstract

Objective: To analyze the electroclinical features and the relationship between the epileptogenic zone (EZ), the tumor and focal cortical dysplasia (FCD) in the three histologic subtypes of dysembryoplastic neuroepithelial tumors (DNTs) ("simple", "complex" and "non-specific forms").

Methods: We analyzed electroclinical data from 78 patients (50 males; 3-54 years) operated for intractable epilepsy due to a DNT. We compared EZ extent, defined by stereo-electroencephalography (n = 33), with the tumor and FCD areas, in each DNT subtype.

Results: Non-specific forms (68%) and temporal location were predominant (73%). The main characteristics consisted of late childhood epilepsy onset (median 12 years), drug-resistant partial seizures and EEG abnormalities concordant with tumor location. In all DNT subtypes, intrinsic epileptogenicity was demonstrated by intralesional recordings (n = 30), displaying a depressed background activity interrupted by rapid spikes or polyspikes. EZ co-localized with the tumor in all simple and complex DNTs, but in only 1/3 of non-specific DNTs. The main discordance between the EZ and tumor extent was found in temporal non-specific DNTs associated with extensive FCD.

Conclusion: These results are helpful when planning surgery for DNTs.

Significance: Intrinsic epileptogenicity characterizes all DNTs; however, the EZ differs according to histologic subtypes and is particularly widespread in non-specific temporal forms.