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Randomized Controlled Trial
. 2013 Apr 30;206(2-3):318-20.
doi: 10.1016/j.psychres.2012.11.008. Epub 2012 Dec 29.

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans

Jennifer C Naylor  1 , Trygve R Dolber, Jennifer L Strauss, Jason D Kilts, Timothy J Strauman, Daniel W Bradford, Steven T Szabo, Nagy A Youssef, Kathryn M Connor, Jonathan R T Davidson, Christine E Marx
Affiliations
Randomized Controlled Trial

A pilot randomized controlled trial with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom era veterans

Jennifer C Naylor et al. Psychiatry Res. .

Abstract

Subthreshold posttraumatic stress disorder (PTSD) is associated with increased risk for suicidality, depression, and functional impairment. We thus conducted a small (N=12) pilot randomized controlled trial (RCT) with paroxetine for subthreshold PTSD in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) era veterans. Hospital Anxiety and Depression Scale (HADS) scores improved by 30.4% in the paroxetine group. Paroxetine may have promise for subthreshold PTSD.

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