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. 2013 Jan;5(1):3-15.
doi: 10.4168/aair.2013.5.1.3. Epub 2012 Nov 28.

Oral immunotherapy for food allergy: towards a new horizon

Evelyne Khoriaty  1 , Dale T Umetsu
Affiliations

Oral immunotherapy for food allergy: towards a new horizon

Evelyne Khoriaty et al. Allergy Asthma Immunol Res. 2013 Jan.

Abstract

Food allergy has increased dramatically in prevalence over the past decade in westernized countries, and is now a major public health problem. Unfortunately for patients with food allergy, there is no effective therapy beyond food allergen avoidance, and rapid medical treatment for accidental exposures. Recently, oral immunotherapy (OIT) has been investigated as a treatment for this problem. In this review, we will discuss the progress in developing OIT for food allergy, including a novel approach utilizing Xolair (anti-IgE monoclonal antibody, omalizumab) in combination with OIT. This combination may enhance both the safety and efficacy of oral immunotherapy, and could lead to a widely available and safe therapy for food allergy.

Keywords: Oral immunotherapy; anti-IgE; desensitization; food allergy; omalizumab; xolair.

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Conflict of interest statement

There are no financial or other issues that might lead to conflict of interest.

Figures

Figure
Figure
Study protocol: Rapid oral desensitization in combination with Omalizumab (xolair) therapy in patients with cow's milk allergy. DBPCFC, double blind placebo controlled food challenge.
See this image and copyright information in PMC

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