Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;13(2):383-9.
doi: 10.1111/ajt.12017. Epub 2012 Dec 27.

Significance of and risk factors for the development of central airway stenosis after lung transplantation

S L Shofer  1 , M M Wahidi, W A Davis, S M Palmer, M G Hartwig, Y Lu, L D Snyder
Affiliations

Significance of and risk factors for the development of central airway stenosis after lung transplantation

S L Shofer et al. Am J Transplant. 2013 Feb.

Abstract

Central airways stenosis (CAS) after lung transplant is a poorly understood complication. Objectives of this study were to determine if CAS was associated with chronic rejection or worse survival after transplant as well as to identify factors associated with CAS in a large cohort of lung transplant recipients. Lung transplant recipients transplanted at a single center were retrospectively reviewed for the development of CAS requiring airway dilation. A total of 467 subjects met inclusion criteria with 60 (13%) of these developing CAS requiring intervention. Of these 60 recipients, 22 (37%) had resolution of CAS with bronchoplasty alone, while 32 (53%) ultimately required stent placement. CAS that required intervention was not a risk factor for the development of bronchiolitis obliterans syndrome or worse overall survival. Significant risk factors for the subsequent development of CAS in a time-dependant multivariable model were pulmonary fungal infections and the need for postoperative tracheostomy. While CAS was not associated with BOS or worse survival, it remains an important complication after lung transplant with potentially preventable risk factors.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: The authors of this manuscript have no conflicts of interest to disclose as described by the American Journal of Transplantation.

Figures

Figure 1
Figure 1
Cohort diagram
See this image and copyright information in PMC

References

    1. Shennib H, Masard G. Airway complications in lung transplantation. Ann Thorac Surg. 1994;57:506–11. - PubMed
    1. Santacruz J, Mehta A. Airway complications and management after lung transplantation. Proc Am Thorac Soc. 2009;6:79–93. - PubMed
    1. Herrera J, McNeil K, Higgins R, Coulden R, Flower C, Nashef S, et al. Airway complications after lung transplantation: treatment and long-term outcome. Ann Thorac Surg. 2001;71:989–94. - PubMed
    1. Moreno P, Alvarez A, Algar F, Cano J, Espinosa D, Cerezo F, et al. Incidence, management and clinical outcomes of patients with airway complications following lung transplantation. Eur J Cardio-Thoracic Surg. 2008;34:1198–205. - PubMed
    1. Murthy S, Blackstone E, Gildea T, Gonzalez-Stawinski G, Feng J, Budev M, et al. Impact of anastomotic airway complications after lung transplantation. Ann Thorac Surg. 2007;84:401–9. - PubMed

Publication types