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. 2013 Feb;47(2):276-8.
doi: 10.1002/mus.23692. Epub 2012 Dec 28.

Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral sclerosis

Evangelos Anagnostou  1 , Michael Rentzos, Theodoros Alexakis, Vasiliki Zouvelou, Thomas Zambelis, Ioannis Evdokimidis
Affiliations

Volume matters: the influence of different botulinum toxin-A dilutions for sialorrhea in amyotrophic lateral sclerosis

Evangelos Anagnostou et al. Muscle Nerve. 2013 Feb.

Erratum in

  • Muscle Nerve. 2013 Jul;48(1):155. Evangelos, Anagnostou [corrected to Anagnostou, Evangelos]; Michael, Rentzos [corrected to Rentzos, Michael]; Theodoros, Alexakis [corrected to Alexakis, Theodoros]; Vasiliki, Zouvelou [corrected to Zouvelou, Vasiliki]; Thomas, Zambelis [corrected to Zambe

Abstract

Introduction: We aimed to determine the effect of different botulinum toxin-A (BTX-A) dilutions on the treatment efficacy and side effects for amyotrophic lateral sclerosis (ALS) related sialorrhea.

Methods: Ten patients were enrolled in the study. BTX-A dilution for Group A was 100 U in 1 ml of saline, whereas the dilution for Group B was 100 U in 2 ml of saline. Both groups received 20 U of BTX-A in each parotid gland, and assessments were made by means of the Drooling Impact Scale, items 1 and 3 of the ALS functional rating scale, and visual analog scales for drooling and swallowing function.

Results: Although both groups exhibited a similar improvement in drooling, Group B had a mild but significant deterioration in bulbar function that was not evident in Group A.

Conclusions: These results suggest that BTX-A has a safer profile when reconstituted with 1 ml instead of 2 ml of saline.

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