Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Nov;5(11):125-47.
doi: 10.1097/WOX.0b013e3182758d6c.

Diagnosis and treatment of urticaria and angioedema: a worldwide perspective

Mario Sánchez-Borges  1 , Riccardo Asero, Ignacio J Ansotegui, Ilaria Baiardini, Jonathan A Bernstein, G Walter Canonica, Richard Gower, David A Kahn, Allen P Kaplan, Connie Katelaris, Marcus Maurer, Hae Sim Park, Paul Potter, Sarbjit Saini, Paolo Tassinari, Alberto Tedeschi, Young Min Ye, Torsten Zuberbier; WAO Scientific and Clinical Issues Council
Affiliations

Diagnosis and treatment of urticaria and angioedema: a worldwide perspective

Mario Sánchez-Borges et al. World Allergy Organ J. 2012 Nov.

Abstract

: Urticaria and angioedema are common clinical conditions representing a major concern for physicians and patients alike. The World Allergy Organization (WAO), recognizing the importance of these diseases, has contributed to previous guidelines for the diagnosis and management of urticaria. The Scientific and Clinical Issues Council of WAO proposed the development of this global Position Paper to further enhance the clinical management of these disorders through the participation of renowned experts from all WAO regions of the world. Sections on definition and classification, prevalence, etiology and pathogenesis, diagnosis, treatment, and prognosis are based on the best scientific evidence presently available. Additional sections devoted to urticaria and angioedema in children and pregnant women, quality of life and patient-reported outcomes, and physical urticarias have been incorporated into this document. It is expected that this article will supplement recent international guidelines with the contribution of an expert panel designated by the WAO, increasing awareness of the importance of urticaria and angioedema in medical practice and will become a useful source of information for optimum patient management worldwide.

PubMed Disclaimer

Figures

Figure 1
Figure 1
A, Provocation testing for physical and cholinergic urticaria
Figure 2
Figure 2
B, Treshold testing for physical urticaria..
Figure 3
Figure 3
Algorithm for the treatment of chronic urticaria.
See this image and copyright information in PMC

Similar articles

  • The challenges of chronic urticaria part 1: Epidemiology, immunopathogenesis, comorbidities, quality of life, and management.
    Sánchez-Borges M, Ansotegui IJ, Baiardini I, Bernstein J, Canonica GW, Ebisawa M, Gomez M, Gonzalez-Diaz SN, Martin B, Morais-Almeida M, Ortega Martell JA. Sánchez-Borges M, et al. World Allergy Organ J. 2021 Jun 1;14(6):100533. doi: 10.1016/j.waojou.2021.100533. eCollection 2021 Jun. World Allergy Organ J. 2021. PMID: 34221215 Free PMC article. Review.
  • The challenges of chronic urticaria part 2: Pharmacological treatment, chronic inducible urticaria, urticaria in special situations.
    Sánchez-Borges M, Ansotegui IJ, Baiardini I, Bernstein J, Canonica GW, Ebisawa M, Gomez RM, González-Diaz S, Martin B, Morais de Almeida M, Ortega Martell JA. Sánchez-Borges M, et al. World Allergy Organ J. 2021 Jun 3;14(6):100546. doi: 10.1016/j.waojou.2021.100546. eCollection 2021 Jun. World Allergy Organ J. 2021. PMID: 34141049 Free PMC article. Review.
  • A Comparison of the United States and International Perspective on Chronic Urticaria Guidelines.
    Zuberbier T, Bernstein JA. Zuberbier T, et al. J Allergy Clin Immunol Pract. 2018 Jul-Aug;6(4):1144-1151. doi: 10.1016/j.jaip.2018.04.012. Epub 2018 May 18. J Allergy Clin Immunol Pract. 2018. PMID: 29779967 Review.
  • The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update.
    Zuberbier T, Aberer W, Asero R, Bindslev-Jensen C, Brzoza Z, Canonica GW, Church MK, Ensina LF, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Hebert J, Hide M, Kaplan A, Kapp A, Abdul Latiff AH, Mathelier-Fusade P, Metz M, Nast A, Saini SS, Sánchez-Borges M, Schmid-Grendelmeier P, Simons FE, Staubach P, Sussman G, Toubi E, Vena GA, Wedi B, Zhu XJ, Maurer M; European Academy of Allergy and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization. Zuberbier T, et al. Allergy. 2014 Jul;69(7):868-87. doi: 10.1111/all.12313. Epub 2014 Apr 30. Allergy. 2014. PMID: 24785199
  • The EAACI/GA²LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria.
    Zuberbier T, Aberer W, Asero R, Abdul Latiff AH, Baker D, Ballmer-Weber B, Bernstein JA, Bindslev-Jensen C, Brzoza Z, Buense Bedrikow R, Canonica GW, Church MK, Craig T, Danilycheva IV, Dressler C, Ensina LF, Giménez-Arnau A, Godse K, Gonçalo M, Grattan C, Hebert J, Hide M, Kaplan A, Kapp A, Katelaris CH, Kocatürk E, Kulthanan K, Larenas-Linnemann D, Leslie TA, Magerl M, Mathelier-Fusade P, Meshkova RY, Metz M, Nast A, Nettis E, Oude-Elberink H, Rosumeck S, Saini SS, Sánchez-Borges M, Schmid-Grendelmeier P, Staubach P, Sussman G, Toubi E, Vena GA, Vestergaard C, Wedi B, Werner RN, Zhao Z, Maurer M; Endorsed by the following societies: AAAAI, AAD, AAIITO, ACAAI, AEDV, APAAACI, ASBAI, ASCIA, BAD, BSACI, CDA, CMICA, CSACI, DDG, DDS, DGAKI, DSA, DST, EAACI, EIAS, EDF, EMBRN, ESCD, GA²LEN, IAACI, IADVL, JDA, NVvA, MSAI, ÖGDV, PSA, RAACI, SBD, SFD, SGAI, SGDV, SIAAIC, SIDeMaST, SPDV, TSD, UNBB, UNEV and WAO. Zuberbier T, et al. Allergy. 2018 Jul;73(7):1393-1414. doi: 10.1111/all.13397. Allergy. 2018. PMID: 29336054
See all similar articles

Cited by

See all "Cited by" articles

References

    1. Poulos LM, Waters AM, Pop Htlh GD, Correll PK, Loblay RH, Marks GB. Trends in hospitalizations for anaphylaxis, angioedema and urticaria in Australia, 1993-1994 to 2004-2005. J Allergy Clin Immunol. 2007;5:878–884. doi: 10.1016/j.jaci.2007.07.040. - DOI - PubMed
    1. Weller K, Altrichter S, Ardelean E, Krause K, Magerl M. et al.Chronic urticaria: prevalence, course, prognostic factors and impact. Hautarzt. 2010;5:750–757. doi: 10.1007/s00105-010-1933-8. - DOI - PubMed
    1. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA. British Society for Allergy and Clinical Immunology (BSACI) et al.BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007;5:631–650. doi: 10.1111/j.1365-2222.2007.02678.x. - DOI - PubMed
    1. Zuberbier T, Asero R, Bindslev-Jensen C, Canonica GW, Church MK. Dermatology Section of the European Academy of Allergology and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization et al.EAACI/GA(2)LEN/EDF/WAO guideline: definition, classification and diagnosis of urticaria. Allergy. 2009;5:1417–1426. doi: 10.1111/j.1398-9995.2009.02179.x. - DOI - PubMed
    1. Zuberbier T, Asero R, Bindslev-Jensen C, Canonica GW, Church MK. Dermatology Section of the European Academy of Allergology and Clinical Immunology; Global Allergy and Asthma European Network; European Dermatology Forum; World Allergy Organization et al.EAACI/GA(2)LEN/EDF/WAO guideline: management of urticaria. Allergy. 2009;5:1427–1443. doi: 10.1111/j.1398-9995.2009.02178.x. - DOI - PubMed