ICON: Eosinophil Disorders

Affiliations

Affiliation

¹ 1Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria 2Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, NIH/NIAID, Bethesda, MD 3Children's Mercy Hospital, Kansas City, MO 4LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France 5Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 6Division of Allergic Diseases, Mayo Clinic, Rochester, MN 7Division of Hematology, Stanford Cancer Center, Stanford, CA 8MLL Münchner Leukämielabor, Munich, Germany 9Department of Hematology, Medical University School of Gdansk, Gdańsk, Poland 10Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany 11Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 12III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany 13Department of Allergy and Immunology, National Research Institute for Children's Health and Development, Tokyo, Japan 14Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 15Division of Allergy and Immunology, Cincinnati Children's Hospital, Medical Center, Cincinnati, OH 16Institute of Pharmacology, University of Bern, Bern, Switzerland 17Center for Human Genetics, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium 18Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 19Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.

PMID: 23282419
PMCID: PMC3651188
DOI: 10.1097/WOX.0b013e31827f4192

ICON: Eosinophil Disorders

Peter Valent et al. World Allergy Organ J. 2012 Dec.

. 2012 Dec;5(12):174-81.

doi: 10.1097/WOX.0b013e31827f4192.

Affiliation

¹ 1Department of Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Austria 2Eosinophil Pathology Unit, Laboratory of Parasitic Diseases, NIH/NIAID, Bethesda, MD 3Children's Mercy Hospital, Kansas City, MO 4LBPA CNRS UMR8113, Ecole Normale Supérieure de Cachan, Cachan, France 5Department of Medicine, Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 6Division of Allergic Diseases, Mayo Clinic, Rochester, MN 7Division of Hematology, Stanford Cancer Center, Stanford, CA 8MLL Münchner Leukämielabor, Munich, Germany 9Department of Hematology, Medical University School of Gdansk, Gdańsk, Poland 10Institute of Pathology, Ludwig-Maximilians-University, Munich, Germany 11Department of Dermatology, University of Utah Health Sciences Center, Salt Lake City, UT 12III. Medizinische Klinik, Universitätsmedizin Mannheim, Universität Heidelberg, Mannheim, Germany 13Department of Allergy and Immunology, National Research Institute for Children's Health and Development, Tokyo, Japan 14Department of Internal Medicine, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium 15Division of Allergy and Immunology, Cincinnati Children's Hospital, Medical Center, Cincinnati, OH 16Institute of Pharmacology, University of Bern, Bern, Switzerland 17Center for Human Genetics, University Hospitals Leuven and Katholieke Universiteit Leuven, Leuven, Belgium 18Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 19Department of Medicine, University of Utah Health Sciences Center, Salt Lake City, UT.

PMID: 23282419
PMCID: PMC3651188
DOI: 10.1097/WOX.0b013e31827f4192

No abstract available

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Figures

**Figure 1**
**Diagnostic Algorithm in patients with Eosinophilia**. In a first step, the presence of eosinophilia or hypereosinophilia (HE) is confirmed. Then, the etiology of eosinophilia/HE is studied, and the patient is examined for the presence of HE-related organ damage. Based on results, patients are classified into various hematologic or immunologic diseases. In those who are suffering from HE-related organopathy, the additional diagnosis of hypereosinophilic syndrome (HES) is established. In a small proportion of cases, familial HES or rare syndromes presenting with HE, such as the Gleich syndrome or Churg Strauss syndrome (CSS), are diagnosed. L-HES, lymphoid variant HES; EMS, eosinophilia myalgia syndrome.

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Radonjic-Hoesli S, Valent P, Klion AD, Wechsler ME, Simon HU. Radonjic-Hoesli S, et al. Annu Rev Pharmacol Toxicol. 2015;55:633-56. doi: 10.1146/annurev-pharmtox-010814-124407. Epub 2014 Oct 17. Annu Rev Pharmacol Toxicol. 2015. PMID: 25340931 Free PMC article. Review.
Eosinophil trafficking in allergen-mediated pulmonary inflammation relies on IL-13-driven CCL-11 and CCL-24 production by tissue fibroblasts and myeloid cells.
Gazzinelli-Guimaraes PH, Golec DP, Karmele EP, Sciurba J, Bara-Garcia P, Hill T, Kang B, Bennuru S, Schwartzberg PL, Nutman TB. Gazzinelli-Guimaraes PH, et al. J Allergy Clin Immunol Glob. 2023 Jun 26;2(4):100131. doi: 10.1016/j.jacig.2023.100131. eCollection 2023 Nov. J Allergy Clin Immunol Glob. 2023. PMID: 37781651 Free PMC article.
Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes.
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Hochhaus A, le Coutre PD, Kantarjian HM, Baccarani M, Erben P, Reiter A, McCulloch T, Fan X, Novick S, Giles FJ. Hochhaus A, et al. J Cancer Res Clin Oncol. 2013 Dec;139(12):1985-93. doi: 10.1007/s00432-013-1529-7. Epub 2013 Sep 22. J Cancer Res Clin Oncol. 2013. PMID: 24057647 Free PMC article. Clinical Trial.
Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC).
Caminati M, Brussino L, Carlucci M, Carlucci P, Carpagnano LF, Caruso C, Cosmi L, D'Amore S, Del Giacco S, Detoraki A, Di Gioacchino M, Matucci A, Mormile I, Granata F, Guarnieri G, Krampera M, Maule M, Nettis E, Nicola S, Noviello S, Pane F, Papayannidis C, Parronchi P, Pelaia G, Ridolo E, Rossi FW, Senna G, Triggiani M, Vacca A, Vivarelli E, Vultaggio A, de Paulis A. Caminati M, et al. Cells. 2024 Jul 11;13(14):1180. doi: 10.3390/cells13141180. Cells. 2024. PMID: 39056762 Free PMC article. Review.

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References

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ICON: Eosinophil Disorders

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ICON: Eosinophil Disorders

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