Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;5(12):182-99.
doi: 10.1097/WOX.0b013e318279affa.

WAO Guideline for the Management of Hereditary Angioedema

Timothy Craig  1 , Emel Aygören-Pürsün, Konrad Bork, Tom Bowen, Henrik Boysen, Henriette Farkas, Anete Grumach, Constance H Katelaris, Richard Lockey, Hilary Longhurst, William Lumry, Markus Magerl, Immaculada Martinez-Saguer, Bruce Ritchie, Alexander Nast, Ruby Pawankar, Bruce Zuraw, Marcus Maurer
Affiliations

WAO Guideline for the Management of Hereditary Angioedema

Timothy Craig et al. World Allergy Organ J. 2012 Dec.

Abstract

: Hereditary Angioedema (HAE) is a rare disease and for this reason proper diagnosis and appropriate therapy are often unknown or not available for physicians and other health care providers. For this reason we convened a group of specialists that focus upon HAE from around the world to develop not only a consensus on diagnosis and management of HAE, but to also provide evidence based grades, strength of evidence and classification for the consensus. Since both consensus and evidence grading were adhered to the document meets criteria as a guideline. The outcome of the guideline is to improve diagnosis and management of patients with HAE throughout the world and to help initiate uniform care and availability of therapies to all with the diagnosis no matter where the residence of the individual with HAE exists.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Literature evaluation form.
Figure 2
Figure 2
Diagnostic algorithm for HAE-1/2. AAE = Acquired angioedema due to C1-INH deficiency.
Figure 3
Figure 3
Treatment algorithm for HAE-1/2.
See this image and copyright information in PMC

References

    1. Brozek JL, Akl EA, Alonso-Coello P, Lang D, Jaeschke R. et al.Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy. 2009;5:669–677. doi: 10.1111/j.1398-9995.2009.01973.x. - DOI - PubMed
    1. Cicardi M, Bork K, Caballero T, Craig T, Li HH, Longhurst H, Reshef A, Zuraw B. Evidence-based recommendations for the therapeutic management of angioedema owing to hereditary C1 inhibitor deficiency: consensus report of an International Working Group. Allergy. 2012;5:147–157. doi: 10.1111/j.1398-9995.2011.02751.x. - DOI - PubMed
    1. Munch EP, Weeke B. Non-hereditary angioedema treated with tranexamic acid. A 6-month placebo controlled trial with follow-up 4 years later. Allergy. 1985;5:92–97. doi: 10.1111/j.1398-9995.1985.tb02666.x. - DOI - PubMed
    1. Lewis JH. Idiopathic gastric acid hypersecretion: treatment implications for refractory acid/peptic disorders. Aliment Pharmacol Ther. 1991;5(suppl 1):15–24. - PubMed
    1. Gluszko P, Undas A, Amenta S, Szczeklik A, Schmaier AH. Administration of gamma interferon in human subjects decreases plasminogen activation and fibrinolysis without influencing C1 inhibitor. J Lab Clin Med. 1994;5:232–240. - PubMed