Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Aug;3(8):223-8.
doi: 10.1097/WOX.0b013e3181ecd8ae.

Staphylococcus aureus and Chronic Airway Disease

Lara Derycke  1 , Claudina Pérez-Novo, Koen Van Crombruggen, Marie-Noëlle Corriveau, Claus Bachert
Affiliations

Staphylococcus aureus and Chronic Airway Disease

Lara Derycke et al. World Allergy Organ J. 2010 Aug.

Abstract

Staphylococcus aureus (S. aureus) is correlated with the development of persistent severe inflammatory disease of the upper airway including chronic rhinosinusitis with nasal polyps. This inflammation of the upper airways is characterized by a T-helper 2-driven disease: interleukin-5 is significantly increased and local production of immunoglobulin E is observed. S. aureus and its enterotoxins are deregulating the tissue inflammation at different levels: structural cells and the innate and adaptive immune system. Knowing the triggers of the pathomechanisms involved will greatly help us to find new therapeutic approaches to resolve this chronic inflammatory process.

PubMed Disclaimer

References

    1. Fokkens W, Lund V, Mullol J. European Position Paper on Rhinosinusitis and Nasal Polyps Group. EP3OS 2007: European position paper on rhinosinusitis and nasal polyps 2007. A summary for otorhinolaryngologists. Rhinology. 2007;3:97–101. - PubMed
    1. Bachert C, Van Bruaene N, Toskala E, Zhang N, Olze H. et al.Important research questions in allergy and related diseases: 3-chronic rhinosinusitis and nasal polyposis - a GALEN study. Allergy. 2009;3:520–533. doi: 10.1111/j.1398-9995.2009.01964.x. - DOI - PubMed
    1. Van Zele T, Gevaert P, Watelet JB, Claeys G, Holtappels G. et al.Staphylococcus aureus colonization and IgE antibody formation to enterotoxins is increased in nasal polyposis. J Allergy Clin Immunol. 2004;3:981–983. doi: 10.1016/j.jaci.2004.07.013. - DOI - PubMed
    1. Sanderson AR, Leid JG, Hunsaker D. Bacterial biofilms on the sinus mucosa of human subjects with chronic rhinosinusitis. Laryngoscope. 2006;3:1121–1126. doi: 10.1097/01.mlg.0000221954.05467.54. - DOI - PubMed
    1. Kluytmans J, van Belkum A, Verbrugh H. Nasal carriage of Staphylococcus aureus: Epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 1997;3:505–520. - PMC - PubMed