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. 2009 Apr;2(4):42-8.
doi: 10.1097/WOX.0b013e31819cdfdb.

Desloratadine therapy improves allergic rhinitis symptoms in latin american children aged 6 to 12 years

Paolo Tassinari  1 , Nelson R Suárez, Jorge Centeno, Janina Vergara Velásquez, Héctor Aguirre-Mariscal, Sandra N Gonzálezdíaz, Alfredo Fernández de Córdova Jerves; LA Desloratadine Study Group
Affiliations

Desloratadine therapy improves allergic rhinitis symptoms in latin american children aged 6 to 12 years

Paolo Tassinari et al. World Allergy Organ J. 2009 Apr.

Abstract

Objective: : To determine the effectiveness of desloratadine syrup in relieving symptoms of allergic rhinitis (AR) among children in Latin America.

Methods: : In an open-label trial conducted in 5 Latin American countries, 455 children aged 6 to 12 years with seasonal or perennial AR were treated with desloratadine syrup 2.5 mg/d for 6 weeks. Thirty percent of subjects were concomitantly taking corticosteroids, and 21.3% had a history of asthma. Efficacy was measured by improvement in the Total Symptom Severity 4 questionnaire and decrease in severity of individual nasal symptoms of congestion, rhinorrhea, pruritus, and sneezing. Physicians and subjects' caregivers rated symptom improvement in a separate assessment at final visit.

Results: : Treatment with desloratadine led to a significant decrease in mean Total Symptom Severity 4 score, from 7.54 at baseline to 1.96 at study end (P < 0.0001), and in individual symptom scores, including congestion (P < 0.0001 for all). Similar improvements were found in groups receiving desloratadine monotherapy and desloratadine plus corticosteroids. Allergic rhinitis symptoms were rated "better" or "much better" by 94% of caregivers. Incidence of adverse events was 6%.

Conclusions: : Desloratadine, with or without concomitant corticosteroids, was efficacious and safe in the treatment of AR in this group of Latin American children.

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Figures

Figure 1
Figure 1
The Total Symptom Severity 4 questionnaire.
Figure 2
Figure 2
Percentage of children with moderate or severe symptoms of AR at baseline.
Figure 3
Figure 3
The TSS4 scores at baseline and after 6 weeks of desloratadine therapy in all subjects and according to the use of concomitant corticosteroid therapy.
Figure 4
Figure 4
Changes in individual symptom scores in all subjects and according to the use of concomitant corticosteroid therapy.
Figure 5
Figure 5
Caregivers' perceptions of improvement.
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