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Case Reports
. 2013 Jan 2:2013:bcr2012007461.
doi: 10.1136/bcr-2012-007461.

Acute lymphoblastic leukaemia presenting with galactorrhoea

Wing Shan Queenie See  1 , Daniel Ka Leung Cheuk, Kong Lam Marcus Fung, Godfrey Chi Fung Chan
Affiliations
Case Reports

Acute lymphoblastic leukaemia presenting with galactorrhoea

Wing Shan Queenie See et al. BMJ Case Rep. .

Abstract

A teenage girl presented with galactorrhoea and moderate hyperprolactinaemia. She was subsequently diagnosed to have acute lymphoblastic leukaemia. Further investigations supported the presence of ectopic prolactin production as suggested by the presence of prolactin mRNA in the patient's marrow at diagnosis. Both the ectopic prolactin mRNA and galactorrhoea eventually resolved upon disease remission after treatment.

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Figures

Figure 1
Figure 1
Gel electrophoresis analysis of amplified cDNA for prolactin gene expression of bone marrow cells before and after chemotherapy. Primer used in PCR would amplify a 276 bp segment in prolactin cDNA. Lanes (A)–(C) were DNA 100 bp ladder, (B) patient's bone marrow sample at diagnosis, (C) patient's bone marrow sample after acute lymphoblastic leukaemia D33 protocol, respectively.
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