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Review
. 2013 Jan 28;52(5):1374-82.
doi: 10.1002/anie.201207535. Epub 2013 Jan 2.

Small-molecule lipid-bilayer anion transporters for biological applications

Nathalie Busschaert  1 , Philip A Gale
Affiliations
Review

Small-molecule lipid-bilayer anion transporters for biological applications

Nathalie Busschaert et al. Angew Chem Int Ed Engl. .

Abstract

The development of small-molecule lipid-bilayer anion transporters for potential future use in channel replacement therapy for the treatment of diseases caused by dysregulation of anion transport (such as cystic fibrosis), and in treating cancer by perturbing chemical gradients within cells, thus triggering apoptosis, is an area of intense current interest. This Minireview looks at recent developments in the design of small-molecule transmembrane anion transporters and focuses on the progress so far in employing these compounds in biological systems.

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