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. 2013 Jan 3:13:1.
doi: 10.1186/1472-6823-13-1.

Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density

Maira L Mendonça  1 , Francisco A Pereira, Marcello H Nogueira-Barbosa, Lucas M Monsignore, Sara R Teixeira, Plauto Ca Watanabe, Lea Mz Maciel, Francisco Ja de Paula
Affiliations

Increased vertebral morphometric fracture in patients with postsurgical hypoparathyroidism despite normal bone mineral density

Maira L Mendonça et al. BMC Endocr Disord. .

Abstract

Background: The mechanism behind parathyroid hormone (PTH) activation of bone remodeling is intimately dependent on the time of exposure of bone cells to hormone levels. Sustained high PTH levels trigger catabolism, while transitory elevations induce anabolism. The effects of hypoparathyroidism (PhPT) on bone are unknown. The objective was to study the impact of PhPT on bone mineral density (BMD), on the frequency of subclinical vertebral fracture and on mandible morphometry.

Methods: The study comprised thirty-three postmenopausal women, 17 controls (CG) and 16 with PhPT (PhPTG) matched for age, weight and height. Bone mineral density (BMD) of lumbar spine, total hip and 1/3 radius, radiographic evaluation of vertebral morphometry, panoramic radiography of the mandible, and biochemical evaluation of mineral metabolism and bone remodeling were evaluated in both groups.

Results: There were no significant differences in lumbar spine or total hip BMD between groups. There was marked heterogeneity of lumbar spine BMD in PhPTG (high = 4, normal = 9, osteopenia = 1, and osteoporosis = 2 patients). BMD was decreased in the 1/3 radius in PhPTG P < 0.005). The PhPTG group exhibited an increased frequency of morphometric vertebral fractures and decreased mandible cortical thickness.

Conclusion: The study suggests that vertebral fragility occurs in PhPT despite normal or even high BMD. The current results encourage further studies to evaluate the use of panoramic radiography in the identification of osteometabolic disorders, such as PhPT and the development of a more physiological treatment for PhPT.

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Figures

Figure 1
Figure 1
Distribution of bone mineral density values of lumbar spine (A), femoral neck (B), total hip (C) and 1/3 d forearm (D) of the control group (CG) and of the postsurgical hypoparathyroidism group (PhPTG).
Figure 2
Figure 2
(Right) Correlation between bone mineral density in lumbar spine and duration of postsurgical hypoparathyroidism (p = 0.03 adjusted by TSH; R2 = 0.35) and (Left) correlation between bone mineral density and cortical thickness of the mental region of the mandible (p < 0.01; R2 = 0.30).
See this image and copyright information in PMC

References

    1. Jilka RL. Molecular and cellular mechanisms of the anabolic effect of intermittent PTH. Bone. 2007;40:1434–1446. doi: 10.1016/j.bone.2007.03.017. - DOI - PMC - PubMed
    1. Jilka RL, O’Brien CA, Bartell SM, Weinstein RS, Manolagas SC. Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms. J Bone Miner Res. 2010;25:2427–2437. doi: 10.1002/jbmr.145. - DOI - PMC - PubMed
    1. de Paula FJ, Rosen CJ. Back to the future: revisiting parathyroid hormone and calcitonin control of bone remodeling. Horm Metab Res. 2010;42:299–306. doi: 10.1055/s-0030-1248255. - DOI - PubMed
    1. Pereira LC, Pereira FA, Sá MF, Foss MC, de Paula FJ. Parathyroid hormone secretion in women in late menopause submitted to EDTA-induced hypocalcemia. Maturitas. 2008;59:91–94. doi: 10.1016/j.maturitas.2007.10.002. - DOI - PubMed
    1. Silverberg SJ, Shane E, de la Cruz L, Segre GV, Clemens TL, Bilezikian JP. Abnormalities in parathyroid hormone secretion and 1,25-diydroxyvitamin D3 formation in women with osteoporosis. N Engl J Med. 1989;320:277–281. doi: 10.1056/NEJM198902023200503. - DOI - PubMed

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