Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Jan 15;12(2):205-6.
doi: 10.4161/cc.23422. Epub 2012 Jan 15.

From photomorphogenesis to cancer: a CSN journey

Leonardo Salmena  1 , Razqallah Hakem
Affiliations
Comment

From photomorphogenesis to cancer: a CSN journey

Leonardo Salmena et al. Cell Cycle. .
No abstract available

Keywords: COP1; COP9; MDM2; SKP2; p53; p57Kip2.

PubMed Disclaimer

Figures

None
Figure 1. The COP9 signalosome (CSN) is a regulator of multiple oncogenic E3-ligases. CSN6 is activated by inputs from activated PI3K kinase pathway, as observed in breast cancers with HER2 amplification. CSN6 controls the activities of the E3 ligases COP1, MDM2 and SKP2. Through COP1, CSN mediates 14–3-3σ degradation, thereby relieving negative regulation of AKT, which, in turn, forms a positive feedback to activate CSN6. By activating MDM2 and SKP2 activity toward their tumor suppressor substrates p53 and p57kip2, respectively, CSN is hypothesized to promote oncogenesis.
See this image and copyright information in PMC

Comment on

Similar articles

See all similar articles

Cited by

References

    1. Wei N, et al. Trends Biochem Sci. 2008;33:592–600. doi: 10.1016/j.tibs.2008.09.004. - DOI - PubMed
    1. Hannss R, et al. FEBS Lett. 2011;585:2845–52. doi: 10.1016/j.febslet.2011.04.027. - DOI - PubMed
    1. Lee MH, et al. Cell Cycle. 2011;10:3057–66. doi: 10.4161/cc.10.18.17320. - DOI - PMC - PubMed
    1. Chamovitz DA. EMBO Rep. 2009;10:352–8. doi: 10.1038/embor.2009.33. - DOI - PMC - PubMed
    1. Zhao R, et al. J Clin Invest. 2011;121:851–65. doi: 10.1172/JCI44111. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources