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. 2013 Feb 21;121(8):e50-6.
doi: 10.1182/blood-2012-05-424846. Epub 2013 Jan 3.

Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors

Kenneth S Cohen  1 , Susan Cheng, Martin G Larson, L Adrienne Cupples, Elizabeth L McCabe, Ying A Wang, Julius S Ngwa, Roderick P Martin, Rachael J Klein, Basma Hashmi, Yin Ge, Christopher J O'Donnell, Ramachandran S Vasan, Stanley Y Shaw, Thomas J Wang
Affiliations

Circulating CD34(+) progenitor cell frequency is associated with clinical and genetic factors

Kenneth S Cohen et al. Blood. .

Abstract

Circulating blood CD34(+) cells consist of hematopoietic stem/progenitor cells, angiogenic cells, and endothelial cells. In addition to their clinical use in hematopoietic stem cell transplantation, CD34(+) cells may also promote therapeutic neovascularization. Therefore, understanding the factors that influence circulating CD34(+) cell frequency has wide implications for vascular biology in addition to stem cell transplantation. In the present study, we examined the clinical and genetic characteristics associated with circulating CD34(+) cell frequency in a large, community-based sample of 1786 Framingham Heart Study participants.Among subjects without cardiovascular disease (n = 1595), CD34(+) frequency was inversely related to older age, female sex, and smoking. CD34(+) frequency was positively related to weight, serum total cholesterol, and statin therapy. Clinical covariates accounted for 6.3% of CD34(+) variability. CD34(+) frequency was highly heritable (h(2) = 54%; P < .0001). Genome-wide association analysis of CD34(+) frequency identified suggestive associations at several loci, including OR4C12 (chromosome 11; P = 6.7 × 10(-7)) and ENO1 and RERE (chromosome 1; P = 8.8 × 10(-7)). CD34(+) cell frequency is reduced in older subjects and is influenced by environmental factors including smoking and statin use. CD34(+) frequency is highly heritable. The results of the present study have implications for therapies that use CD34(+) cell populations and support efforts to better understand the genetic mechanisms that underlie CD34(+) frequency.

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Figures

Figure 1
Figure 1
Distribution of P values for the association of individual SNPs with CD34+ according to chromosome number and position.
See this image and copyright information in PMC

References

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