Making healthy stem cells: the new role of TPO
- PMID: 23290133
- DOI: 10.1016/j.stem.2012.12.008
Making healthy stem cells: the new role of TPO
Abstract
Thrombopoietin (TPO) attracts much attention as an effective stimulus for blood cell formation in patients with hematopoietic disorders. In this issue of Cell Stem Cell, de Laval et al. (2013) show that TPO can also promote "healthy" hematopoietic stem cells when administered before radiotherapy to minimize HSC injury and mutagenesis in mice.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Thrombopoietin-increased DNA-PK-dependent DNA repair limits hematopoietic stem and progenitor cell mutagenesis in response to DNA damage.Cell Stem Cell. 2013 Jan 3;12(1):37-48. doi: 10.1016/j.stem.2012.10.012. Epub 2012 Dec 13. Cell Stem Cell. 2013. PMID: 23246483
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