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. 2012 Aug;8(8):504-12.

Vaccination issues in patients with inflammatory bowel disease receiving immunosuppression

Seper Dezfoli  1 , Gil Y Melmed
Affiliations

Vaccination issues in patients with inflammatory bowel disease receiving immunosuppression

Seper Dezfoli et al. Gastroenterol Hepatol (N Y). 2012 Aug.

Abstract

Treatment regimens for Crohn's disease and ulcerative colitis increase susceptibility to infections, many of which can be prevented by vaccinations. Increased awareness concerning vaccine-preventable diseases has led to several studies investigating the immunologic responses to vaccines in immunosuppressed patients with inflammatory bowel disease. This review provides an overview of the evidence-based rationale for currently accepted recommendations regarding the use of both inactivated and live vaccines in this unique population.

Keywords: Inflammatory bowel disease; immunization; infection; pertussis; pneumococcal vaccine; vaccination.

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References

    1. Melmed G, Ippoliti A, Papadakis K, et al. Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses. Am J Gastroenterol. 2006;101:1834–1840. - PubMed
    1. Bernal I, Domenech E, Garcia-Planella E, et al. Opportunistic infections in patients with inflammatory bowel disease undergoing immunosuppressive therapy. Gastroenterol Hepatol. 2003;26:19–22. - PubMed
    1. Toruner M, Loftus E, Jr, Harmsen W, et al. Risk factors for opportunistic infections in patients with inflammatory bowel disease. Gastroenterology. 2008;134:929–936. - PubMed
    1. Viget N, Vernier-Massouille G, Salmon-Ceron D, et al. Opportunistic infections in patients with inflammatory bowel disease: prevention and diagnosis. Gut. 2008;57:549–558. - PubMed
    1. Ostuni P, Botsios C, Punzi L, et al. Hepatitis B reactivation in a chronic hepatitis B surface antigen carrier with rheumatoid arthritis treated with infliximab and low dose methotrexate. Ann Rheum Dis. 2003;62:686–687. - PMC - PubMed

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