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Review
. 2013 Jan;8(1):154-61.
doi: 10.2215/CJN.05870612.

Lupus nephritis: treatment of resistant disease

Sean Kalloo  1 , Nidhi Aggarwal, Prince Mohan, Jai Radhakrishnan
Affiliations
Review

Lupus nephritis: treatment of resistant disease

Sean Kalloo et al. Clin J Am Soc Nephrol. 2013 Jan.

Abstract

Lupus nephritis (LN) remains a major cause of ESRD and is associated with a >4-fold increase in mortality and significant morbidity in patients with lupus. The treatment of LN has evolved significantly over the past decade due to data from well conducted randomized controlled trials. We are currently in an era in which effective regimens exist in the form of induction and maintenance agents. Histopathologic classification of LN remains one of the main factors guiding therapy.

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Figures

Figure 1.
Figure 1.. Suggested treatment algorithm for resistant lupus nephritis.
Resistant indicates 25% decline in estimated GFR or ESRD, 100% increase in urinary protein/urinary creatinine ratio, or the presence of an active urinary sediment. LN, lupus nephritis; MMF, mycophenolate mofetil; NIH, National Institutes of Health; ELNT, Euro-Lupus Nephritis Trial; CYC, cyclophosphamide; CNI, calcineurin inhibitor.
See this image and copyright information in PMC

Comment in

  • Lupus nephritis: keeping the wolf at bay.
    Radhakrishnan J. Radhakrishnan J. Clin J Am Soc Nephrol. 2013 Jan;8(1):136-7. doi: 10.2215/CJN.09500912. Clin J Am Soc Nephrol. 2013. PMID: 23296379 Free PMC article. No abstract available.

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