Individual variation in glucocorticoid stress responses in animals

Abstract

When stimuli from the environment are perceived to be a threat or potential threat then animals initiate stress responses, with activation of the hypothalamo-pituitary-adrenal axis and secretion of glucocorticoid hormones (cortisol and corticosterone). Whilst standard deviation or standard error values are always reported, it is only when graphs of individual responses are shown that the extensive variation between animals is apparent. Some animals have little or no response to a stressor that evokes a relatively large response in others. Glucocorticoid responses of fish, amphibian, reptiles, birds, and mammals are considered in this review. Comparisons of responses between animals and groups of animals focused on responses to restraint or confinement as relatively standard stressors. Individual graphs could not be found in the literature for glucocorticoid responses to capture or restraint in fish or reptiles, with just one graph in mammals with the first sample was collected when animals were initially restrained. Coefficients of variation (CVs) calculated for parameters of glucocorticoid stress responses showed that the relative magnitudes of variation were similar in different vertebrate groups. The overall mean CV for glucocorticoid concentrations in initial (0 min) samples was 74.5%, and CVs for samples collected over various times up to 4 h were consistently between 50% and 60%. The factors that lead to the observed individual variation and the extent to which this variation is adaptive or non-adaptive are little known in most animals, and future studies of glucocorticoid responses in animals can focus on individual responses and their origins and significance.