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. 2013 Mar;99(3):e37-41.
doi: 10.1016/j.diabres.2012.12.007. Epub 2013 Jan 5.

Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes

Deep Dutta  1 , Subhadip Choudhuri, Samim Ali Mondal, Indira Maisnam, Abu Hena Hasanoor Reza, Sujoy Ghosh, Subhankar Chowdhury, Basudev Bhattacharya, Satinath Mukhopadhyay
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Tumor necrosis factor alpha -238G/A (rs 361525) gene polymorphism predicts progression to type-2 diabetes in an Eastern Indian population with prediabetes

Deep Dutta et al. Diabetes Res Clin Pract. 2013 Mar.

Abstract

Prediabetes (IPD; n=122) and normoglycemic individuals (n=100) underwent assessment of polymorphisms of TNFα (-238, -308) and IL6 (-174). After 27.25±5.64 months, 16 IPD had reverted to normoglycemia and 18 progressed to diabetes. TNFα -238AA/GA genotypes were significantly more common in IPD, had higher TNFα, higher progression to diabetes and lower reversal.

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