Cutaneous pigmentation in health and disease: novel and well-established players
- PMID: 23299449
- DOI: 10.1038/jid.2012.442
Cutaneous pigmentation in health and disease: novel and well-established players
Abstract
Cutaneous pigment formation and aberration in disease are addressed. Dynoodt et al. (this issue) present data on a specific micro RNA that downregulates proteins involved in melanogenesis and melanosome movement. Kim et al. (this issue) present data showing that Wnt signaling is involved in the pathogenesis of melasma. Both articles enhance our understanding of cutaneous pigmentation and point to targets in the development of novel therapeutic modalities.
Comment on
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Identification of miR-145 as a key regulator of the pigmentary process.J Invest Dermatol. 2013 Jan;133(1):201-9. doi: 10.1038/jid.2012.266. Epub 2012 Aug 16. J Invest Dermatol. 2013. PMID: 22895360
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Reduced WIF-1 expression stimulates skin hyperpigmentation in patients with melasma.J Invest Dermatol. 2013 Jan;133(1):191-200. doi: 10.1038/jid.2012.270. Epub 2012 Sep 6. J Invest Dermatol. 2013. PMID: 22951732
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