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. 2013 Jan 9;11(1):2.
doi: 10.1186/1476-7120-11-2.

The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population

Hack-Lyoung Kim  1 , Moon-Sun Im, Jae-Bin Seo, Woo-Young Chung, Sang-Hyun Kim, Myung-A Kim, Joo-Hee Zo
Affiliations

The association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population

Hack-Lyoung Kim et al. Cardiovasc Ultrasound. .

Abstract

Background: The aim of this study is to investigate the association between arterial stiffness and left ventricular filling pressure in an apparently healthy Korean population.

Methods: A total of 115 healthy subjects without known cardiovascular risk factors or overt heart disease who underwent both transthoracic echocardiography and brachial-ankle pulse wave velocity (baPWV) measurement at the same day during their routine check-ups were analyzed.

Results: The mean age of study subjects was 52.8 ± 8.4 years, and 78 (67.8%) were men. The mean baPWV value was 1,325 ± 185 cm/s. Study subjects were divided into 3 groups according to E/E' value: subjects with E/E' < 8, 8-12.9 and E/E' ≥ 13. As E/E' increased, baPWV value increased gradually: baPWV in subjects with E/E' < 8, E/E' 8-12.9 and E/E' ≥ 13, were 1,261 ± 163, 1,345 ± 169, 1,569 ± 232 cm/s, respectively (p < 0.001). In multiple linear regression analyses, baPWV was significantly associated with E/E' (β = 0.371, p < 0.001) after controlling confounders including age, sex and body mass index. In receiver-operating characteristic (ROC) curve analysis, the sensitivity and specificity for detection of E/E' ≥ 10 were 78.6% and 59.8%, respectively with mean baPWV of 1,282 cm/s as the cut off value. The discriminatory capacity for predicting E/E' ≥ 10 was improved from an area under the ROC curve of 0.646 with age alone to 0.734 when baPWV was added (p < 0.001).

Conclusions: There is a significant association between baPWV and E/E' in an apparently healthy Korean population. BaPWV is useful as a simple and non-invasive method for early detection of increased LV filling pressure among these people.

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Figures

Figure 1
Figure 1
Scatter plot showing the association between baPWV and E/E’. BaPVW, brachial-ankle pulse wave velocity.
Figure 2
Figure 2
ROC curve of baPWV for prediction of E/E’ ≥ 10. ROC, receiver operating characteristics; baPVW, brachial-ankle pulse wave velocity. AUC, area under curve; CI, confidence interval.
Figure 3
Figure 3
Incremental ROC analysis for prediction of E/E’ ≥ 10. ROC, receiver operating characteristics; baPVW, brachial-ankle pulse wave velocity.
See this image and copyright information in PMC

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