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Comment
. 2013 Jan;31(1):31-2.
doi: 10.1038/nbt.2480.

Reprogramming paces the heart

Edward G Lakatta  1 , Victor A Maltsev
Affiliations
Comment

Reprogramming paces the heart

Edward G Lakatta et al. Nat Biotechnol. 2013 Jan.

Abstract

Rodent cardiomyocytes are converted into pacemaker cells by viral delivery of a single transcription-factor gene.

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Figures

Figure 1
Figure 1
The coupled-clock pacemaker cell system. The same regulatory factors or nodes (red lettering) couple intracellular Ca2+ to surface-membrane proteins to generate rhythmic spontaneous action potentials at rest. β-adrenergic and cholinergic receptor activation change action potential firing rate via signaling through the same nodes. Musical notes at the ion channels and also same notes during action potential schematically illustrate the sequence of their activation underlying rhythmic and robust pacemaker function.
See this image and copyright information in PMC

Comment on

References

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    1. Lakatta EG, Maltsev VA, Vinogradova TM. A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart’s pacemaker. Circ Res. 2010;106:659–673. - PMC - PubMed

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