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Review
. 2013 May;60(5):728-33.
doi: 10.1002/pbc.24464. Epub 2013 Jan 9.

Epidemiology of childhood acute myeloid leukemia

Susan E Puumala  1 , Julie A Ross, Richard Aplenc, Logan G Spector
Affiliations
Review

Epidemiology of childhood acute myeloid leukemia

Susan E Puumala et al. Pediatr Blood Cancer. 2013 May.

Abstract

Although leukemia is the most common childhood cancer diagnosis, the subtype, acute myeloid leukemia (AML), is less common and fewer etiologic studies exist. This review summarizes the major risk factors for AML. We searched the literature using PubMed for articles on childhood AML and reviewed 180 articles. While few risk factors are definitive, we identified several with consistent evidence of a possible effect. Thorough analysis of genetic and epigenetic factors is missing from this literature and methodological issues are unresolved. Future studies should more closely examine causal mechanisms, improve exposure measurement, and include analysis using genetic and epigenetic factors.

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Conflict of interest statement

Conflict of Interest Statement: The authors declare that they have no conflict of interest to report.

Figures

Figure 1
Figure 1. Incidence rates for AML by age at diagnosis, U.S. SEER 1992-2004a
a Adapted from data presented in Linabery and Ross[2].
See this image and copyright information in PMC

References

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