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Comment
. 2013 Jan 9;5(167):167ps1.
doi: 10.1126/scitranslmed.3005411.

Repurposing the Pap smear: one step closer to gynecologic cancer screening

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Comment

Repurposing the Pap smear: one step closer to gynecologic cancer screening

Shannon N Westin et al. Sci Transl Med. .

Abstract

Prevention and early detection remain essential to decreasing cancer mortality. Screening DNA in Pap smears has the potential to increase the rate of early detection of endometrial and ovarian cancers. In this issue of Science Translational Medicine, Kinde and colleagues use advanced sequencing technology to evaluate DNA to screen for gynecologic malignancies.

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DNA evaluation of cervical cytology is possible through genomic analysis of the liquid fixative of the liquid-based test.

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References

    1. Wingo PA, et al. Long-term trends in cancer mortality in the United States, 1930–1998. Cancer. 2003 Jun 15;97:3133. - PubMed
    1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA: a cancer journal for clinicians. 2012 Jan-Feb;62:10. - PubMed
    1. Jacobs I, et al. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncol. 2011 Jan;12:38. - PubMed
    1. Buys SS, et al. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA. 2011 Jun 8;305:2295. - PubMed
    1. Arbyn M, et al. Liquid compared with conventional cervical cytology: a systematic review and meta-analysis. Obstet Gynecol. 2008 Jan;111:167. - PubMed

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