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Review
. 2012:123:126-33; discussion 133-4.

Pierre Ménétrier and his disease

Robert J Coffey Jr  1 , Jarred Tanksley
Affiliations
Review

Pierre Ménétrier and his disease

Robert J Coffey Jr et al. Trans Am Clin Climatol Assoc. 2012.

Abstract

In 1888, Pierre Ménétrier first described the disease that bears his name. Many of the findings he reported then remain accepted features of the disease. Based on studies performed in our laboratory over the past 20 years, we have implicated increased transforming growth factor-α (TGFα) expression and heightened epidermal growth factor receptor (EGFR) activity in the pathogenesis of Ménétrier's disease. Herein, we provide a historical perspective of this rare disorder, review our experience with Ménétrier's disease, and discuss future challenges and opportunities posed by this disorder.

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Conflict of interest statement

Potential Conflicts of Interest: None disclosed.

Figures

Fig. 1
Fig. 1
Pierre Ménétrier's original drawing of Ménétrier's disease. See text for details.
Fig. 2
Fig. 2
Expanded proliferative zone within a region of foveolar hyperplasia. See text for details.
See this image and copyright information in PMC

References

    1. Menetrier P. Des polyadenomes gastriques et leur rapport avecle cancer de l'estomac. Arch Physiol Norm Pathol. 1888;1:32–55. 236–62.
    1. Rich A, Toro TZ, Tanksley J, et al. Distinguishing Menetrier's disease from its mimics. Gut. 2010;59:1617–24. - PMC - PubMed
    1. Wolfsen HC, Carpenter HA, Talley NJ. Menetrier's disease: a form of hypertrophic gastropathy or gastritis? Gastroenterology. 1993;104:1310–9. - PubMed
    1. Coffey RJ, Jr, Derynck R, Wilcox JN, et al. Production and auto-induction of transforming growth factor-alpha in human keratinocytes. Nature. 1987;328:817–20. - PubMed
    1. Beauchamp RD, Barnard JA, McCutchen CM, Cherner JA, Coffey RJ., Jr Localization of transforming growth factor alpha and its receptor in gastric mucosal cells. Implications for a regulatory role in acid secretion and mucosal renewal. J Clin Invest. 1989;84:1017–23. - PMC - PubMed

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