Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar-Apr;31(2):234-42.
Epub 2013 Jan 7.

Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study

Ljudmila Stojanovich  1 , Milica Kontic, Aleksandra Djokovic, Dragomir Marisavljevic, Nenad Ilijevski, Natasa Stanisavljevic, Zeljko Mikovic, Milena Petkovic, Vladimir Kovcin
Affiliations
  • PMID: 23306109

Association between systemic non-criteria APS manifestations and antibody type and level: results from the Serbian national cohort study

Ljudmila Stojanovich et al. Clin Exp Rheumatol. 2013 Mar-Apr.

Abstract

Objectives: The aim of this study was to investigate the importance of aPL type and level for non-criteria-related events in APS patients.

Methods: Our study included 374 patients: 260 with PAPS and 114 with APS associated with systemic lupus erythematosus (SLE).

Results: We discovered significant connection between migraine and LA absence, livedo reticularis and aCL-IgG, skin ulcerations with aCL-IgG and anti-β2GPI-IgM, pseudovasculitis lesions with aCL-IgG, aCL-IgM and anti-β2GPI-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG and anti-β2GPI-IgG. Thrombocytopenia occurred more frequently in patients with more than one aPL. In PAPS, epilepsy correlated with ß2GPI-IgM, migraine with aCL-IgM, and thrombocytopenia with aCL-IgM, aCL-IgG, anti ß2GPI-IgG and LA. Skin ulcerations occurred more frequently in IIc category patients and in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Livedo reticularis was more prominent in PAPS with high levels of aCL-IgG. Significantly higher prevalence of thrombocytopenia was observed in patients with high levels of aCL-IgG and anti ß2GPI-IgG. Epilepsy was related to high levels of anti ß2GPI-IgM and thrombocytopenia in the SAPS was correlated with aCL-IgG. Skin ulcerations were more prevalent in aCL-IgM positive SAPS patients and epilepsy more frequently in SAPS patients with high levels of anti ß2GPI-IgG.

Conclusions: Our study showed that certain aPL type with certain level correlated with non-criteria manifestations, suggesting their predictive role.

PubMed Disclaimer

MeSH terms