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. 2013 Feb 18;49(14):1401-3.
doi: 10.1039/c2cc38349g.

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

Xuejian Li  1 , Yanyan Zhao, Haijun Qu, Zhenjun Mao, Xufeng Lin
Affiliations

Organocatalytic asymmetric multicomponent reactions of aromatic aldehydes and anilines with β-ketoesters: facile and atom-economical access to chiral tetrahydropyridines

Xuejian Li et al. Chem Commun (Camb). .

Abstract

The first catalytic asymmetric pseudo five-component (AB(2)C(2) type) reaction is reported. A spirocyclic chiral phosphoric acid catalyzed one-pot multicomponent reaction of aromatic aldehydes, anilines and β-ketoesters and afforded highly functionalized enantioenriched tetrahydropyridines with high levels of stereocontrol.

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