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. 2013 Jan;131(1):110-1.
doi: 10.1001/jamaophthalmol.2013.572.

Square root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of age-related eye disease study report no. 26

William J Feuer, Zohar Yehoshua, Giovanni Gregori, Fernando M Penha, Emily Y Chew, Frederick L Ferris, Traci E Clemons, Anne S Lindblad, Philip J Rosenfeld

Square root transformation of geographic atrophy area measurements to eliminate dependence of growth rates on baseline lesion measurements: a reanalysis of age-related eye disease study report no. 26

William J Feuer et al. JAMA Ophthalmol. 2013 Jan.
No abstract available

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Ferris is one of the inventors on US patent 6 660 297, “Nutritional Supplement to Treat Macular Degeneration,” issued on December 9, 2003, and owned by Bausch & Lomb; Dr Ferris has assigned his interest in the patent to the US government and receives government compensation. Dr Rosenfeld is a consultant to Acucela, Boehringer Ingelheim, Chengdu Kanghong Biotech, and Oraya; receives research support from Advanced Cell Technology, Alexion Pharmaceuticals, and GlaxoSmithKline; receives research support and lecture fees from Carl Zeiss Meditec; and is an advisor to Sucampo Pharmaceuticals and ThromboGenics.

Figures

Figure.
Figure.
Change in area of geographic atrophy using the standard area measurements and the square root transformation of these area measurements. A, Original analysis showing the change in area over 4 years for each of the baseline size categories. B, Revised analysis showing the change in the square root of the area measurements for each of the baseline size categories. DA indicates disc areas.
See this image and copyright information in PMC

References

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