Comment
doi: 10.1016/j.cmet.2012.11.011.
Tipping the energy balance toward longevity
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- PMID: 23312278
- DOI: 10.1016/j.cmet.2012.11.011
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Comment
Tipping the energy balance toward longevity
Cell Metab.
.
Free article
Abstract
AMPK is a cellular energy sensor conserved across eukaryotes that in C. elegans prolongs life span and mimics dietary restriction. Stenesen and colleagues (2012) activate AMPK both directly and indirectly by altering AMP biosynthesis to slow aging in Drosophila, highlighting AMPK as a conserved life span modulator that links energy sensing to longevity.
Copyright © 2013 Elsevier Inc. All rights reserved.
Comment on
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Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.Cell Metab. 2013 Jan 8;17(1):101-12. doi: 10.1016/j.cmet.2012.12.006. Cell Metab. 2013. PMID: 23312286 Free PMC article.
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