Chlorpyrifos-induced changes in oxidant/antioxidant status and haematological parameters of Cyprinus carpio carpio: ameliorative effect of lycopene
- PMID: 23312461
- DOI: 10.1016/j.chemosphere.2012.12.006
Chlorpyrifos-induced changes in oxidant/antioxidant status and haematological parameters of Cyprinus carpio carpio: ameliorative effect of lycopene
Abstract
The present study was carried out to investigate the potential ameliorative effects of lycopene against chlorpyrifos (CPF) toxicity in carp. The fish were divided into 7 different experimental groups and received the following treatments: Group 1, control; Group 2, orally administered corn oil; Group 3, oral lycopene (10 mg kg(-1) body weight); Group 4, exposure to 0.040 mg L(-1) CPF; Group 5, exposure to 0.040 mg L(-1) CPF plus oral administration of 10 mg kg(-1) lycopene; Group 6, exposure to 0.080 mg L(-1) CPF; and Group 7, exposure to 0.040 mg L(-1) CPF plus oral administration of 10 mg kg(-1) lycopene. Treatment was continued for 14 d and samples of the blood and tissue (liver, kidney, and gill) were collected at the end of the experiment and analysed for their oxidant-antioxidant status, including the malondialdehyde (MDA) levels, and the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) activity. The samples were also measured for changes in the haematological parameters, such as the red blood cell (RBC) and white blood cell (WBC) counts, the haemoglobin concentration (Hb), the haematocrit (Ht) level, and the erythrocyte indices: the mean corpuscular volume (MCV), the mean corpuscular haemoglobin (MCH) and the mean corpuscular haemoglobin concentration (MCHC). The findings of this study demonstrated that CPF had a negative effect on the haematological parameters and the antioxidant enzyme activities of the fish; this toxic effect was neutralised by the administration of lycopene. The present results suggest that lycopene (10 mg kg(-1)) can be effective in the protection of CPF-induced toxicity in fish.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
Protective role of propolis in chlorpyrifos-induced changes in the haematological parameters and the oxidative/antioxidative status of Cyprinus carpio carpio.Food Chem Toxicol. 2012 Aug;50(8):2703-8. doi: 10.1016/j.fct.2012.05.032. Epub 2012 May 22. Food Chem Toxicol. 2012. PMID: 22634289
-
Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure.Environ Toxicol. 2013 Nov;28(11):609-16. doi: 10.1002/tox.20757. Epub 2011 Aug 25. Environ Toxicol. 2013. PMID: 24150867
-
Chlorpyrifos-induced biochemical changes in Cyprinus carpio: Ameliorative effect of curcumin.Ecotoxicol Environ Saf. 2018 Apr 30;151:49-54. doi: 10.1016/j.ecoenv.2017.12.065. Epub 2018 Jan 3. Ecotoxicol Environ Saf. 2018. PMID: 29306070
-
Erythrocyte osmotic fragility and lipid peroxidation following chronic co-exposure of rats to chlorpyrifos and deltamethrin, and the beneficial effect of alpha-lipoic acid.Toxicol Rep. 2014 Jul 12;1:373-378. doi: 10.1016/j.toxrep.2014.07.002. eCollection 2014. Toxicol Rep. 2014. PMID: 28962253 Free PMC article. Review.
-
Haematological parameters as bioindicators of insecticide exposure in teleosts.Ecotoxicology. 2010 Jun;19(5):838-54. doi: 10.1007/s10646-010-0465-4. Epub 2010 Feb 23. Ecotoxicology. 2010. PMID: 20177774 Review.
Cited by
-
In vivo antioxidative and neuroprotective effect of 4-Allyl-2-methoxyphenol against chlorpyrifos-induced neurotoxicity in rat brain.Mol Cell Biochem. 2014 Mar;388(1-2):61-74. doi: 10.1007/s11010-013-1899-9. Epub 2013 Dec 1. Mol Cell Biochem. 2014. PMID: 24292926
-
Tissue-specific responses of oxidative stress biomarkers and antioxidant defenses in rainbow trout Oncorhynchus mykiss during a vaccination against furunculosis.Fish Physiol Biochem. 2014 Aug;40(4):1289-300. doi: 10.1007/s10695-014-9924-9. Epub 2014 Mar 6. Fish Physiol Biochem. 2014. PMID: 24599827 Free PMC article.
-
Effects of chlorpyrifos on the crustacean Litopenaeus vannamei.PLoS One. 2020 Apr 13;15(4):e0231310. doi: 10.1371/journal.pone.0231310. eCollection 2020. PLoS One. 2020. PMID: 32282847 Free PMC article.
-
N-Acetylcysteine Ameliorates Gentamicin-Induced Nephrotoxicity by Enhancing Autophagy and Reducing Oxidative Damage in Miniature Pigs.Shock. 2019 Dec;52(6):622-630. doi: 10.1097/SHK.0000000000001319. Shock. 2019. PMID: 30676497 Free PMC article.
-
Modulatory effect of lycopene against carbofuran toxicity in African catfish, Clarias gariepinus.Fish Physiol Biochem. 2017 Dec;43(6):1721-1731. doi: 10.1007/s10695-017-0404-x. Epub 2017 Jul 18. Fish Physiol Biochem. 2017. PMID: 28721486 Clinical Trial.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous