Spp1 links sites of meiotic DNA double-strand breaks to chromosome axes

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Bernard de Massy. Mol Cell. 2013.

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. 2013 Jan 10;49(1):3-5.

doi: 10.1016/j.molcel.2012.12.011.

¹ Institute of Human Genetics, UPR1142, CNRS, 141 rue de la Cardonille, 34396 Montpellier Cedex 5, France. bernard.de-massy@igh.cnrs.fr

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The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination.
Acquaviva L, Székvölgyi L, Dichtl B, Dichtl BS, de La Roche Saint André C, Nicolas A, Géli V. Acquaviva L, et al. Science. 2013 Jan 11;339(6116):215-8. doi: 10.1126/science.1225739. Epub 2012 Nov 15. Science. 2013. PMID: 23160953
Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes.
Sommermeyer V, Béneut C, Chaplais E, Serrentino ME, Borde V. Sommermeyer V, et al. Mol Cell. 2013 Jan 10;49(1):43-54. doi: 10.1016/j.molcel.2012.11.008. Epub 2012 Dec 13. Mol Cell. 2013. PMID: 23246437