Comment on

• 2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial.

  Gallwitz B, Rosenstock J, Rauch T, Bhattacharya S, Patel S, von Eynatten M, Dugi KA, Woerle HJ. Gallwitz B, et al. Lancet. 2012 Aug 4;380(9840):475-83. doi: 10.1016/S0140-6736(12)60691-6. Epub 2012 Jun 28. Lancet. 2012. PMID: 22748821 Clinical Trial.
• Preregistration of study design and non-inferiority margin.

  van Hateren KJ, Kleefstra N, Bilo HJ. van Hateren KJ, et al. Lancet. 2013 Jan 12;381(9861):115. doi: 10.1016/S0140-6736(13)60047-1. Lancet. 2013. PMID: 23312753 No abstract available.