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. 2013 Feb;115(2):249-53.
doi: 10.1016/j.oooo.2012.11.011.

Evidence for loss of heterozygosity (LOH) at chromosomes 9p and 17p in oral granular cell tumors: a pilot study

Carolina Cavaliéri Gomes  1 , Thiago Fonseca-Silva, Ricardo Santiago Gomez
Affiliations
Free article

Evidence for loss of heterozygosity (LOH) at chromosomes 9p and 17p in oral granular cell tumors: a pilot study

Carolina Cavaliéri Gomes et al. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Feb.
Free article

Abstract

Objective: The objective of this study was to assess loss of heterozygosity (LOH) in tumor suppressor gene loci in oral granular cell tumors (GCTs).

Study design: We assessed LOH in 8 samples of oral GCT using polymorphic microsatellite markers at chromosome regions 3p, 9p, 11q, and 17p, flanking areas close to tumor suppressor genes. We further performed immunohistochemistry to detect the p53 and Ki-67 proteins and associated these expressions with the molecular results.

Results: Five samples showed LOH in 3 markers at chromosomes 9p and 17p (markers P53, AFM238WF2 and D9S162) with fraction of allelic loss of 42.8% for each of these markers. No LOH was identified in any other chromosome. LOH was not associated with the immunohistochemical expression of p53 and Ki-67.

Conclusions: The present study shows LOH at chromosomes 9p and 17p in oral GCTs.

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